Preview : This Monograph describes the state of art of the immunomodulator P-MAPA, that has been scientifically studied since the 80s by Brazilian, Chilean, European and American scientists.Its chemical and physical characteristics, biological properties, pre-clinical results and clinical trials results will be detailed and discussed, in order to explore its potential uses as a therapeutic


Antiviral Research-Volume 83, Issue 2, August 2009

Punta Toro virus, has been adapted to induce a Rift Valley fever virus-like disease in C57BL/6 mice. This virus has been used as a model to study the potential role of immunomodulating substances in therapies. Here, we report findings on the use of P-MAPA as an antiviral agent in a mouse model of acute phleboviral (Punta Toro virus) disease


Immunopharmacology and Immunotoxicology - Volume 25, Number 3 / 2003

Preview :The present study examined the effects of P-MAPA, an antitumor aggregated polymer of protein magnesium ammonium phospholinoleate-palmitoleate anhydride, isolated from Aspergillus oryzae, on concanavalin A-induced spleen cell proliferation, cytokine production and on NK cell activity in Ehrlich ascites tumor-bearing mice.


Nanonization on biotechnological product: Nanocrystals and its polymorphisms-7 th Brazilian MRS Meeting 2008

Preview : The aim of present work was to compare two different nanonization processes starting from crystals of P-MAPA with size around 200μm


Nitric Oxide 14 - 2006 Macrophage nitric oxide -NO- stimulation by an immunomodulator: P-MAPA

Preview : this study asseded the ability of P-MAPA to modulate NO production by macrophages purified from peritoneal cavity of thioglycolate-treated mice


2nd World Conference - Ehrlich II - Nürnberg - 2008 -Structure and Antimalarial Activity of Immunomodulator P-MAPA

Preview : The P-MAPA activity against malaria ( Plasmodium chabaudi) was evaluated in groups of 7-10 C57BL/6 female mice, 5-8 week-old and pathogen-free.

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