SETTING: Tuberculosis (TB) program in Ensenada, Mexico.
OBJECTIVE: To evaluate the impact of the DOTS strategy on adherence and cure rates in everyday practice.
DESIGN: Retrospective analysis of 629 patients diagnosed with TB.
MEASUREMENTS AND RESULTS: A total of 70% of the patients under directly observed treatment (DOT) were cured vs. 72.8% of those under self-administered treatment (SAT, P = 0.57). There was no difference on the length of therapy according to treatment regimen (4.82 ± 2.41 for DOT vs. 4.93 ± 2.16 for SAT, P = 0.61); 16.8% of patients under DOT abandoned treatment vs. 14.1% in the SAT group (P = 0.40). Logistic regression analysis confirmed the previous findings, with length of treatment under 6 months being the strongest predictive variable for treatment failure (OR 18.8, P < 0.00). The type of regimen (DOT vs. SAT) was not predictive of treatment failure (OR for failure for SAT regimen 0.65, P = 0.14).
CONCLUSIONS: Cure and completion of treatment rates in our population under study did not differ significantly when comparing DOT vs. SAT. Those in charge of the DOTS programs in a given country need to assess which are the most important ingredients for success in their particular program.
Keywords: tuberculosis; treatment; DOT; results; Mexico
Authors: Radilla-Chávez, P.1; Laniado-Laborín, R.2
Source: The International Journal of Tuberculosis and Lung Disease, Volume 11, Number 3, March 2007 , pp. 289-292(4)