Authors: Buijtels, P.C.A.M.1; van de Sande, W.W.J.2; Parkinson, S.3; Petit, P.L.C.4; van der Sande, M.A.B.5; van Soolingen, D.6; Verbrugh, H.A.2; van Belkum, A.2

Source: The International Journal of Tuberculosis and Lung Disease, Volume 12, Number 12, December 2008 , pp. 1485-1488(4)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the −2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5). 
Keywords: polymorphism; CCL2; tuberculosis; Africa; Zambia

Document Type: Short communication

Affiliations: 1: Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands; Department of Medical Microbiology, Medical Centre Rijnmond-Zuid, Rotterdam, The Netherlands 2: Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands 3: St. Francis Hospital, Katete, Zambia 4: Department of Medical Microbiology, Vlietland Hospital, Schiedam, The Netherlands 5: Centre for Infectious Diseases Control, Epidemiology and Surveillance, National Institute of Public Health and the Environment, Bilthoven, The Netherlands 6: National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Saiba mais em: http://www.ingentaconnect.com/content/iuatld/ijtld/2008/00000012/00000012/art00025

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