1. Ducati, Rodrigo G.; Breda, A; Basso, Luiz Augusto; Santos, Diógenes S. Purine Salvage Pathway in Mycobacterium tuberculosis.Current Medicinal Chemistry. 2011 Mar 2. [Epub ahead of print] PMID: 21366536 [PubMed - as supplied by publisher]

2. Villela, Anne D; Sánchez-Quitian, Zilpa A, Ducati, Rodrigo G.; Santos, Diógenes S.; Basso, Luiz Augusto. Pyrimidine Salvage Pathway in Mycobacterium tuberculosis. Current Medicinal Chemistry. 2011 Mar 2. [Epub ahead of print] PMID: 21366534 [PubMed - as supplied by publisher]

3. Saidemberg, D. M.; Passarelli, A.W.; Rodrigues, A. V.; Basso, Luiz Augusto; Santos, Diogenes S, Palma Mário S. Shikimate Kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: Kinetics and Structural Dynamics of a Potential Molecular Target for Drug Development. Current Medicinal Chemistry. 2011 Mar 2. [Epub ahead of print] PMID: 21366533 [PubMed - as supplied by publisher]

4. Sánchez-Quitian, Zilpa A.; Timmers L. F.; Caceres R. A.; Gonçalves, J. R.; Thompson, C. E.; Basso, Luiz Augusto; de Azevedo, Walter F. Jr.; Santos, Diogenes S. Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products. Archives of Biochemistry and Biophysics. 2011 Feb 2. [Epub ahead of print] PMID: 21295009 [PubMed - as supplied by publisher]

5. Rostirolla, Diana C.; Breda, A.; Rosado, L. A.; Palma, Mário S.; Basso, Luiz Augusto; Santos, Diógenes S. UMP kinase fromMycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation. Archives of Biochemistry and Biophysics. v. 505, p. 202-212, 2011.

6. Sánchez-Quitian, Zilpa A.; Schneider, Cristopher Z.; Ducati, Rodrigo G.; de Azevedo Junior, Walter F.; Bloch Junior, Carlos; Basso, Luiz Augusto; Santos, Diógenes S. Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase. Journal of Structural Biology, v. 169, p. 413-423, 2010.

7. Ducati, Rodrigo G.; Basso, Luiz Augusto; Santos, Diógenes S.; de Azevedo Jr., Walter F. Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry, v. 18, p. 4769-4774, 2010.

8. Vasconcelos, Igor. B.; Basso, Luiz Augusto; Santos, Diogenes Santiago. Kinetic equilibrium mechanisms of substrate binding toMycobacterium tuberculosis enoyl reductase: implications to function-based antitubercular agent design. Journal of the Brazilian Chemical Society (Impresso), v. 21, p. 1503-1508, 2010.

9. Basso, Luiz Augusto; Schneider, Cristopher Z.; Santos, A. J. A. B.; Santos JR., A. A.; Campos Maria M.; Souto, André A.; Santos, Diogenes S. An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis. Journal of the Brazilian Chemical Society (Impresso), v. 21, p. 1384-1389, 2010.

10. Vaso, Alessandra; dos Santos, Diógenes S.; Basso, Luiz Augusto; Palma, Mario S. Hydrogen/deuterium exchange mass spectrometry for characterizing phosphoenolpyruvate-induced structural transitions in Mycobacterium tuberculosis 5-enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.1). International Journal of Mass Spectrometry (Print), p. 1-7, 2010.

11. Thum, Caroline; Schneider, Cristopher Z.; Palma, Mario S.; Santos, Diógenes S.; Basso, Luiz Augusto. The Rv1712 Locus fromMycobacterium tuberculosis H37Rv Codes for a Functional CMP Kinase That Preferentially Phosphorylates dCMP. Journal of Bacteriology, v. 191, p. 2884-2887, 2009.

12. Biazus, Gisele; Schneider, Cristopher Z.; Palma, Mario S.; Basso, Luiz Augusto; Santos, Diógenes S. Hypoxanthine guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: Cloning, expression, and biochemical characterization. Protein Expression and Purification, v. 66, p. 185-190, 2009.

13. Rodrigues Junior, Valnês S.; Basso, Luiz Augusto; Santos, Diógenes S. Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: an essential step towards target-based drug design. International Journal of Biological Macromolecules, v. 45, p. 200-205, 2009.

14. Werlang, Isabel C. R.; Schneider, Cristopher Z.; Mendonça, Jordana D.; Palma, Mario S.; Basso, Luiz Augusto; Santos, Diogenes S . Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis. Microbiology (Reading), v. 155, p. 2652-2663, 2009.

15. Ducati, Rodrigo G.; Santos, Diogenes S.; Basso, Luiz Augusto. Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics, v. 486, p. 155-164, 2009.

16. Rodrigues Junior, Valnês S.; Breda, Ardala; Santos, Diógenes Santiago; Basso, Luiz Augusto. The conserved lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase. BMC Research Notes, v. 2, p. 227-227, 2009.

17. Czekster, Clarissa M.; Neto, Brenno A.D.; Lapis, Alexandre A.M.; Dupont, Jairton; Santos, Diogenes S.; Basso, Luiz Augusto. Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics (Print), v. 486, p. 19-26, 2009.

18. Schneider, Cristopher Z.; Parish, T.; Basso, Luiz Augusto; Santos, Diogenes S. The two chorismate mutases fromMycobacterium tuberculosis and Mycobacterium smegmatis: biochemical analysis and limited regulation of promoter activity by aromatic amino acids. Journal of Bacteriology, v. 190, p. 122-134, 2008.

19. Arcuri, Helen Andrade; Borges, J. C.; Fonseca, Isabel O.; Pereira, José Henrique; Ruggiero Neto, J.; Basso, Luiz Augusto; Santos, Diogenes S.; Azevedo, Walter Filgueira de. Structural studies of shikimate-5-dehydrogenase from Mycobacterium tuberculosis. Proteins, v. 72, p. 720-730, 2008.

20. Silva, Rafael G.; Rosado, Leonardo Altolfi; Santos, Diogenes S; Basso, Luiz Augusto. Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding. Archives of Biochemistry and Biophysics, v. 471, p. 1-10, 2008.

21. Caceres, Rafael Andrade; Macedo Timmers, Luís Fernando Saraiva; Vivan, Ana Luiza; Schneider, Cristopher Zandoná; Basso, Luiz Augusto; Azevedo, Walter Filgueira; Santos, Diogenes Santiago. Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv. Journal of Molecular Modeling, v. 14, p. 427-434, 2008.

22. Vivan, Ana L.; Caceres, Rafael A.; Abrego, J. R. B.; Borges, J. C.; Ruggiero Neto, J.; Ramos, C. H. I.; AZEVEDO, Walter Filgueira de; Basso, Luiz Augusto; SANTOS, Diogenes S. Structural studies of prephenate dehydratase from Mycobacterium tuberculosisH37Rv by SAXS, ultracentrifugation, and computational analysis. Proteins, v. 72, p. 1352-1362, 2008.

23. Vasconcelos, Igor B.; Meyer, E.; Sales, F. A. M.; Moreira, Ícaro S.; Basso, Luiz Augusto; Santos, Diogenes S. The mode of inhibition of Mycobacterium tuberculosis wild-type and isoniazid-resistant 2-trans-enoyl-ACP(CoA) reductase enzymes by an inorganic complex. Anti-infective Agents in Medicinal Chemistry, v. 7, p. 50-62, 2008. 

24. Ely, Fernanda; Nunes, José E. S.; Schroeder, Evelyn K.; Frazzon, Jeverson; Palma, Mário S.; Santos, Diogenes S; Basso, Luiz Augusto. The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase. BMC Biochemistry (Online), v. 9, p. 13, 2008.

25. Marques, M. R.; Silva, A. V. R.; Ruggiero Neto, F.; Fossey, M. A.; Oliveira, J. S.; Basso, Luiz Augusto; Santos, Diógenes S; Azevedo, Walter Filgueira de; Palma, Mário Sérgio . Dynamics of glyphosate-induced conformational changes of Mycobacterium tuberculosis 5-enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) determined by hydrogen-deuterium exchange and electrospray mass spectrometry. Biochemistry (Easton), v. 47, p. 7509-7522, 2008.

26. Czekster, C; Lapis, A; Souza, G; Eberlin, M; Basso, Luiz Augusto; Santos, Diógenes S; Dupont, Jairton; Neto, Breno. The catalytic mechanism of indole-3-glycerol phosphate synthase (IGPS) investigated by electrospray ionization (tandem) mass spectrometry. Tetrahedron Letters, v. 49, p. 5914-5917, 2008.

27. Breda, A.; Basso, Luiz Augusto; Santos, Diógenes S; Azevedo, Walter Filgueira de. Virtual Screening of Drugs: Score Functions, Docking, and Drug Design. Current Computer-Aided Drug Design, v. 4, p. 265-272, 2008. 

Sobre a Rede TB

A Rede Brasileira de Pesquisa em Tuberculose (REDE-TB) é uma Organização Não Governamental (ONG) de direito privado sem fins lucrativos, preocupada em auxiliar no desenvolvimento não só de novos medicamentos, novas vacinas, novos testes diagnósticos e novas estratégias de controle de TB, mas também na validação dessas inovações tecnológicas, antes de sua comercialização no país e/ou de sua implementação nos Programa de Controle de TB no País.


bt2

Contato

E-mail: redetb.rp@gmail.com

Tel: +55 (21)3938 - 2426
Tel/ Fax: +55 (21)3938 - 2431.

Endereço: Avenida Carlos Chagas Filho, 791, Cidade Universitária - Ilha do Fundão, Rio de Janeiro, RJ - Brasil. CEP: 21941-904

Assine a newsletter da Rede TB

Curta Rede TB no Facebook