F. Aguiar, M. A. Vieira, A. Staviack, C. Buarque, A. Marsico, L. Fonseca, R. Chaisson, A. Kristski, G. Werneck, F. Mello


S E T T I N G :    A    reference    hospital    for    tuberculosis    (TB) and human immunodeficiency virus/acquired immune- deficiency syndrome (HIV/AIDS) with a TB control pro- gramme in Rio de Janeiro, Brazil.


OBJECTIVE:    To estimate the prevalence of resistance to anti-tuberculosis drugs and to identify associated factors.

Attachments:
Download this file (1340_prevalence.pdf)1340_prevalence.pdf[ ]174 kB
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Elis R Dalla Costa, Marta O Ribeiro, Márcia SN Silva, Liane S Arnold, Diana C Rostirolla, Patricia I Cafrune, Roger C Espinoza, Moises Palaci, Maria A Telles, Viviana Ritacco, Philip N Suffys, Maria L Lopes, Creuza L Campelo, Silvana S Miranda, Kristin Kremer, Pedro E Almeida da Silva, Leila de Souza Fonseca, John L Ho, Afrânio L Kritski and Maria LR Rossetti



ABSTRACT


Background

Mutations associated with resistance to rifampin or streptomycin have been reported for W/Beijing and Latin American Mediterranean (LAM) strain families of Mycobacterium tuberculosis. A few studies with limited sample sizes have separately evaluated mutations in katG, ahpC and inhA genes that are associated with isoniazid (INH) resistance. Increasing prevalence of INH resistance, especially in high tuberculosis (TB) prevalent countries is worsening the burden of TB control programs, since similar transmission rates are noted for INH susceptible and resistant M. tuberculosis strains.
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Brito, R.C.; Mello, F.C.Q.; Andrade, M.K.; Oliveira, H.; Costa, W.; Matos, H.J.; Lourenço, M.C.; Rolla, V.C.; Fonseca, L.; Ruffino Netto, A.; Kritski, A.L.

SETTING: Tuberculosis (TB) drug resistance survey in six hospitals in Rio de Janeiro, Brazil.

 
OBJECTIVE: To estimate resistance to at least one drug (DR) and multidrug resistance (MDR) and identify associated factors. DESIGN: One-year cross-sectional survey. Hospitals were included as a convenience sample.
Attachments:
Download this file (907_Drug-resistant TB.pdf)907_Drug-resistant TB.pdf[ ]135 kB
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Joycenea Matsuda Mendes, Maria Cristina Lourenço, Rosa Maria Carvalho Ferreira, Leila de Souza Fonseca, Maria Helena Feres Saad


Abstract:


This study aimed to assess drug resistance in Mycobacterium tuberculosis strains isolated from sputum samples. To that end, sputum samples were collected from 263 patients suspected of having tuberculosis. All subjects lived in the Complexo de Manguinhos, which is located in the city of Rio de Janeiro, Brazil. Cultures testing positive between October of 2000 and December of 2002 were tested to determine strain susceptibility to isoniazid, rifampicin, streptomycin, ethionamide, and ethambutol. Of the 75 patients diagnosed with tuberculosis, resistance to at least one of the drugs was found in 16 (21.4%). Of those 16 patients, 8 (50%) were new cases, and 8 (50%) had previously been treated. Multidrug-resistant tuberculosis was identified in 8 (10.6%) of the 75 patients, being associated with previous treatment in 6 (8%). The incidence of multidrug-resistant tuberculosis might have been underestimated, since M. tuberculosis was not isolated from all of the samples testing positive for acid-fast bacilli. However, at least, our findings shed some light on the problem. 


Keywords: Tuberculosis; Drug resistance; Drug resistance, multiple. 

Attachments:
Download this file (1333_2007_33_5_14_english.pdf)1333_2007_33_5_14_english.pdf[ ]86 kB

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A Rede Brasileira de Pesquisa em Tuberculose (REDE-TB) é uma Organização Não Governamental (ONG) de direito privado sem fins lucrativos, preocupada em auxiliar no desenvolvimento não só de novos medicamentos, novas vacinas, novos testes diagnósticos e novas estratégias de controle de TB, mas também na validação dessas inovações tecnológicas, antes de sua comercialização no país e/ou de sua implementação nos Programa de Controle de TB no País.


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