Rita M. Zorzenon dos Santos, Ana Amador, Wayner V. de Souza, Maria Fatima P. M. de Albuquerque, Silvina Ponce Dawson, Antonio Ruffino-Netto, Carlos R. Zárate-Bladés, Celio L. Silva

Abstract


Background: Detailed analysis of the dynamic interactions among biological, environmental, social, and economic factors that favour the spread of certain diseases is extremely useful for designing effective control strategies. Diseases like tuberculosis that kills somebody every 15 seconds in the world, require methods that take into account the disease dynamics to design truly efficient control and surveillance strategies. The usual and well established statistical approaches provide insights into the cause-effect relationships that favour disease transmission but they only estimate risk areas, spatial or temporal trends. Here we introduce a novel approach that allows figuring out the dynamical behaviour of the disease spreading. This information can subsequently be used to validate mathematical models of the dissemination process from which the underlying mechanisms that are responsible for this spreading could be inferred.

Attachments:
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Background

Interferon-gamma (IFN-gamma) Release Assays (IGRA) are more specific than the tuberculosis skin test (TST) in the diagnosis of latent tuberculosis (TB) infection (LTBI). We present the performance of the QuantiFERON-TB Gold In-tube (QFT-TB) assay as diagnostic test and during follow-up of preventive TB therapy in outpatients from a TB low-endemic country.

Background The aim of this study was to investigate the molecular characteristics of isoniazid resistant Mycobacterium tuberculosis (MTB), as well as its contribution to the dissemination of multi-drug resistant TB (MDR-TB) in rural areas of eastern China.

Methods A population-based epidemiological study was conducted in two rural counties of eastern China from 2004 to 2005. In total, 131 isoniazid resistant MTB isolates were molecularly characterized by DNA sequencing and genotyped by IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping.

Brazilian and American scientists have demonstrated that a compound known as P-Mapa is active against Mycobacterium tuberculosis in vivo. These results they say may pave the way for the use of this compound in the treatment of tuberculosis and other infectious diseases on humans.

P-Mapa is the acronym for a compound chemically classified as the proteinaceous aggregate of ammonium and magnesium phospholinoleate-palmitoleate anhydride. It has been developed since the 1990s by a group of Brazilian, Chilean and American scientists led by the non-profit research network Farmabrasilis. Tests on TB and other pathogens were carried out in the US by the National Institute of Allergy and Infectious Diseases (NIAID) teams.

Sobre a REDE-TB

A Rede Brasileira de Pesquisa em Tuberculose (REDE-TB) é uma Organização Não Governamental (ONG) de direito privado sem fins lucrativos, preocupada em auxiliar no desenvolvimento não só de novos medicamentos, novas vacinas, novos testes diagnósticos e novas estratégias de controle de TB, mas também na validação dessas inovações tecnológicas, antes de sua comercialização no país e/ou de sua implementação nos Programa de Controle de TB no País.


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