Madhukar Pai, MD, PhD; Alice Zwerling, MSc; and Dick Menzies, MD, MSc
Background: Interferon- γ –release assays (IGRAs) are alternatives to the tuberculin skin test (TST). A recent meta-analysis showed that IGRAs have high specificity, even among populations that have received bacille Calmette–Gue´ rin (BCG) vaccination. Sensitivity was suboptimal for TST and IGRAs.
Purpose: To incorporate newly reported evidence from 20 studies into an updated meta-analysis on the sensitivity and specificity of IGRAs.